Impact of transferable β-lactamases and intrinsic AmpC amino acid substitutions on the activity of cefiderocol against wild-type and iron uptake-deficient mutants of <i>Pseudomonas aeruginosa</i>
We add evidence about the effect of the interplay between iron uptake and β-lactamases on the acquisition of cefiderocol resistance in P. aeruginosa. These findings may help to anticipate the emergence of resistance and optimize the use of cefiderocol against P. aeruginosa infections.
Authors
- Pablo A. Fraile-Ribot (ORCID: https://orcid.org/0000-0002-3822-9965)
- Salud Rodríguez-Pallares (ORCID: https://orcid.org/0000-0002-8270-0259)
- Michelle Outeda-García (ORCID: https://orcid.org/0000-0002-6737-0239)
- Juan Carlos Vázquez-Ucha (ORCID: https://orcid.org/0000-0003-4949-0779)
- Concepción González‐Bello (ORCID: https://orcid.org/0000-0001-6439-553X)
- Alejandro Beceiro (ORCID: https://orcid.org/0000-0002-6340-7815)
- Antonio Oliver (ORCID: https://orcid.org/0000-0001-9327-1894)
- Tania Blanco-Martín (ORCID: https://orcid.org/0009-0003-1636-6429)
- Jorge Arca-Suárez (ORCID: https://orcid.org/0000-0002-4248-503X)
- Maria Antonia Gomis-Font (ORCID: https://orcid.org/0000-0001-6042-5674)
- Isaac Alonso-García (ORCID: https://orcid.org/0000-0002-1681-969X)
- Germán Bou (ORCID: https://orcid.org/0000-0001-8837-0062)
- Lucía González-Pinto (ORCID: https://orcid.org/0000-0002-8387-3784)
Institutions
- Universidade de Santiago de Compostela (ES)
- Instituto de Salud Carlos III (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Health Research Institute of the Balearic Islands (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Son Espases (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1093/jac/dkae326
- Citations
- 10
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Pfizer
- European Commission
- Shionogi
- Consellería de Economía, Emprego e Industria, Xunta de Galicia
- Axencia Galega de Innovación
- Xunta de Galicia
- Wockhardt
- Centro Singular de Investigación de Galicia
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación