Mitochondrial dysfunction in platelets from severe trauma patients - A prospective case-control study
The present study revealed that severe trauma is associated with platelet mitochondrial dysfunction resulting in reduced ATP synthesis and impaired extramitochondrial Ca<sup>2+</sup> movement. These factors are required for platelet activation, recruitment and clot stability likely thus, platelet mitochondrial dysfunction contributes to the development of TIC.
Authors
- Péter Jávor (ORCID: https://orcid.org/0000-0002-5628-9355)
- Bálint Baráth (ORCID: https://orcid.org/0000-0001-8837-2375)
- Dávid Kurszán Jász (ORCID: https://orcid.org/0000-0003-3700-5668)
- Tibor Donka (ORCID: https://orcid.org/0000-0003-3793-9647)
- Lilla Sándor (ORCID: https://orcid.org/0000-0002-0530-763X)
- Domonkos Perényi
- Petra Hartmann (ORCID: https://orcid.org/0000-0002-4746-9792)
- Barna Babik (ORCID: https://orcid.org/0000-0003-3739-8879)
- László Török (ORCID: https://orcid.org/0000-0001-9287-524X)
- Endre Varga (ORCID: https://orcid.org/0000-0002-7397-2965)
Institutions
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
Publication Details
- Journal
- Injury
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.injury.2024.111481
- Citations
- 4
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 1.69
Funders
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Nemzeti Kutatási és Technológiai Hivatal
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- National Research, Development and Innovation Office