Enteric glial <scp>NLRP3</scp> inflammasome contributes to gut mucosal barrier alterations in a mouse model of diet‐induced obesity
HFD intake elicits mucosal enteric gliotic processes characterized by a hyperactivation of NLRP3/caspase-1/IL-1β signaling pathway, that contributes to further exacerbate the disruption of intestinal mucosal barrier integrity. However, we cannot rule out the contribution of NLRP3 inflammasome activation from other cells, such as immune cells, in IEB alterations associated with obesity. Overall, our results suggest that enteric glial NLRP3 inflammasome might represent an interesting molecular target for the development of novel pharmacological approaches aimed at managing the enteric inflammation and intestinal mucosal dysfunctions associated with obesity.
Authors
- Cristina Segnani
- Clelia Di Salvo (ORCID: https://orcid.org/0009-0002-7083-4214)
- Chiara Ippolito (ORCID: https://orcid.org/0000-0001-8671-313X)
- Nunzia Bernardini (ORCID: https://orcid.org/0000-0001-9061-9402)
- Anna Nericcio
- Vanessa D’Antongiovanni (ORCID: https://orcid.org/0000-0002-3303-0674)
- Matteo Fornai (ORCID: https://orcid.org/0000-0002-0812-3959)
- György Haskó
- Luca Antonioli (ORCID: https://orcid.org/0000-0003-1241-617X)
- Rocchina Colucci (ORCID: https://orcid.org/0000-0002-2593-5457)
- Carolina Pellegrini (ORCID: https://orcid.org/0000-0003-2644-5430)
- Laura Benvenuti (ORCID: https://orcid.org/0000-0001-6576-5053)
- Zoltán H. Németh (ORCID: https://orcid.org/0000-0002-9282-6322)
- Clarissa Pierucci
Institutions
- University of Pisa (IT)
- University of Padua (IT)
- Columbia University Irving Medical Center (US)
- Morristown Medical Center (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1111/apha.14232
- Citations
- 8
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- Università di Pisa