Adenosine A2B receptor activation regulates the balance between T helper 17 cells and regulatory T cells, and inhibits regulatory T cells exhaustion in experimental autoimmune myositis
The exhausted T cells may be pathogenic in IIM, and the activation of adenosine A2B receptor signalling pathway can regulate Th17/Treg balance and inhibit Tregs exhaustion, thereby slowing EAM disease progression.
Authors
- Geng Yin (ORCID: https://orcid.org/0000-0002-1336-9072)
- Qibing Xie (ORCID: https://orcid.org/0000-0002-6727-1839)
- Yueyuan Zhou (ORCID: https://orcid.org/0000-0002-3765-2585)
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0002-7998-6444)
- Bo Chen (ORCID: https://orcid.org/0000-0001-5748-8551)
- Leiyi Yang
- Binhan Liu
- Limei Kang
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/jcsm.13581
- Citations
- 9
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 3.48
Funders
- Sichuan Province Science and Technology Support Program