Identification of antibody targets associated with lower HIV viral load and viremic control
We identified HIV antibody targets associated with lower VL and HIV controller status 1-2 years after infection. Robust aggregate responses to these targets and broad antibody reactivity across the HIV genome were also associated with lower VL and controller status. These findings provide novel insights into the relationship between humoral immunity and viral containment that could help inform the design of antibody-based approaches for reducing HIV VL.
Authors
- Sarah E. Hudelson
- Oliver Laeyendecker (ORCID: https://orcid.org/0000-0002-6429-4760)
- William Clarke
- William R. Morgenlander (ORCID: https://orcid.org/0000-0001-7205-3732)
- Peter Bock (ORCID: https://orcid.org/0000-0003-3211-6078)
- Sue‐Ann Meehan (ORCID: https://orcid.org/0000-0002-0826-1833)
- Estelle Piwowar‐Manning (ORCID: https://orcid.org/0000-0002-6501-0440)
- Helen Ayles (ORCID: https://orcid.org/0000-0003-4108-2842)
- Kwame Shanaube (ORCID: https://orcid.org/0000-0001-7899-0890)
- Autumn Breaud
- Barry R. Kosloff (ORCID: https://orcid.org/0000-0002-8074-2586)
- Kai Kammers (ORCID: https://orcid.org/0000-0001-5548-7942)
- H. Benjamin Larman (ORCID: https://orcid.org/0000-0001-7863-196X)
- Wendy Grant‐McAuley
- Sarah Fidler (ORCID: https://orcid.org/0000-0003-1676-7583)
- Ayana Moore (ORCID: https://orcid.org/0000-0002-1216-6337)
- Susan H. Eshleman (ORCID: https://orcid.org/0000-0002-4587-791X)
- Ingo Ruczinski (ORCID: https://orcid.org/0000-0003-3278-6274)
- Richard Hayes (ORCID: https://orcid.org/0000-0002-1729-9892)
- Manjusha Thakar (ORCID: https://orcid.org/0009-0005-8886-6443)
- Anneen van Deventer
Institutions
- Family Health International 360 (US)
- National Institutes of Health (US)
- Desmond Tutu HIV Foundation (ZA)
- Johns Hopkins University (US)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- University of Zambia (ZM)
- London School of Hygiene & Tropical Medicine (GB)
- National Institute of Allergy and Infectious Diseases (US)
- Zambart (ZM)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Imperial College London (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1371/journal.pone.0305976
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Bill and Melinda Gates Foundation
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- U.S. President’s Emergency Plan for AIDS Relief
- Department for International Development, UK Government
- European Commission
- Department for International Development
- National Institutes of Health
- Medical Research Council
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research
- European and Developing Countries Clinical Trials Partnership