Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy <i>bla</i> <sub>KPC-2</sub> to <i>bla</i> <sub>KPC-189</sub> during treatment of ST11 carbapenem-resistant <i>Klebsiella pneumoniae</i>
To date, ceftazidime-avibactam (CZA) resistance caused by double-copy <i>Klebsiella pneumoniae</i> carbapenemase (KPC) variants has not been elucidated. The multicopy forms of carbapenem resistance genes carried by the same plasmid are relatively rare in most carbapenem-resistant <i>Enterobacteriaceae</i>. In this study, we elucidate the evolutionary trajectory of CZA resistance in ST11 carbapenem-resistant <i>K. pneumoniae</i> harboring a double-copy blaKPC and provide new insights into the mechanisms of acquired resistance to CZA.
Authors
- Tailong Lei (ORCID: https://orcid.org/0000-0003-2067-1787)
- Jiayao Yao
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Haiyang Liu (ORCID: https://orcid.org/0000-0001-6332-6751)
- Jintao He (ORCID: https://orcid.org/0000-0002-4412-9661)
- Lin Liu (ORCID: https://orcid.org/0000-0002-3716-8857)
- Yuexing Tu (ORCID: https://orcid.org/0000-0003-3073-8746)
- Xi Li (ORCID: https://orcid.org/0000-0002-8838-7814)
- Xiaofan Zhang (ORCID: https://orcid.org/0000-0003-1025-164X)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4363-5666)
- Longjie Zhou
- Yinrong Xie
Institutions
- Union Hospital (HK)
- Sir Run Run Shaw Hospital (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Zoucheng People's Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1128/msystems.00722-24
- Citations
- 17
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.90
Funders
- National Natural Science Foundation of China