LincR-PPP2R5C deficiency enhancing the fungicidal activity of neutrophils in pulmonary cryptococcosis is linked to the upregulation of IL-4
Pulmonary cryptococcosis is a human fungal disease caused by <i>Cryptococcus neoformans</i>, which is common not only in immunocompromised individuals but also in patients with normal immune function. Therefore, studying the control mechanisms of pulmonary cryptococcosis is highly important. Here, we demonstrated that the deletion of LincR-PPP2R5C leads to increased killing of <i>C. neoformans</i> by neutrophils, thereby reducing pulmonary cryptococcal infection. These findings will greatly enhance our understanding of the mechanisms by which lncRNAs regulate the pathogenesis of <i>C. neoformans</i>, facilitating the use of lncRNAs in pulmonary cryptococcosis therapy.
Authors
- Mingshun Zhang (ORCID: https://orcid.org/0000-0001-5925-0168)
- Xia Zhang (ORCID: https://orcid.org/0009-0003-5167-7054)
- Yang Chen (ORCID: https://orcid.org/0009-0000-1119-3715)
- Ying Gong (ORCID: https://orcid.org/0000-0002-4338-3764)
- Ting Wang (ORCID: https://orcid.org/0000-0001-7406-892X)
- Shan Liu (ORCID: https://orcid.org/0000-0002-5230-8870)
- Yonglin Yang (ORCID: https://orcid.org/0000-0003-3162-4070)
- Xin Chen (ORCID: https://orcid.org/0000-0002-5579-0447)
- Chunan Sun
- Wei Liu (ORCID: https://orcid.org/0000-0003-2018-7004)
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- mBio
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1128/mbio.02130-24
- Citations
- 2
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China
- Nanjing Medical University