Circulating ECM proteins decorin and alpha-L-iduronidase differentiate ATTRwt-CM from ATTRwt-negative HFpEF/HFmrEF
ATTRwt-CM has a distinctly different biomarker profile compared with HFpEF/HFmrEF, while ATTRwt-CM patients share a similar biomarker profile with AL-CM patients characterized by up-regulation of proteoglycans and cell-adhesion pathways. The biomarkers DCN and IDUA show the potential to serve as an initial screening tool for ATTTRwt-CM. Further research is needed to determine the clinical usefulness of these and other extracellular matrix components in identifying ATTRwt-CM.
Authors
- Riemer H. J. A. Slart (ORCID: https://orcid.org/0000-0002-5565-1164)
- Hans Nienhuis (ORCID: https://orcid.org/0000-0003-3974-6830)
- Bouke P. C. Hazenberg (ORCID: https://orcid.org/0000-0003-1827-0482)
- Laura M G Meems (ORCID: https://orcid.org/0000-0001-8627-7139)
- Lukas Baumhove (ORCID: https://orcid.org/0000-0002-5860-7943)
- Johan Bijzet (ORCID: https://orcid.org/0000-0002-0375-4460)
- George Markousis‐Mavrogenis (ORCID: https://orcid.org/0000-0001-8192-6670)
- Alwin Tubben (ORCID: https://orcid.org/0000-0001-8414-958X)
- Bart J. van Essen (ORCID: https://orcid.org/0000-0002-9057-7449)
- Dirk Jan van Veldhuisen (ORCID: https://orcid.org/0000-0003-1611-7935)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Milou Berends (ORCID: https://orcid.org/0009-0003-1056-0482)
- Hendrea S. A. Tingen (ORCID: https://orcid.org/0000-0002-8572-9428)
- Peter van der Meer (ORCID: https://orcid.org/0000-0002-9705-4413)
Institutions
- University Medical Center Groningen (NL)
- Amyloidosis Foundation (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1093/cvr/cvae189
- Citations
- 6
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.40