Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial
These results confirm the efficacy and tolerability of darolutamide plus ADT in patients with mHSPC, demonstrating clinically and statistically significant improvement in rPFS and a favorable safety profile consistent with prior phase III darolutamide trials.
Authors
- Egils Vjaters (ORCID: https://orcid.org/0000-0003-0054-3745)
- Sudhir Rawal (ORCID: https://orcid.org/0000-0002-3331-2372)
- Praveena Voonna
- Dahong Zhang (ORCID: https://orcid.org/0000-0002-9869-0577)
- Yongsheng Yang (ORCID: https://orcid.org/0000-0002-7546-1210)
- D.E. Castellano Gauna
- Murilo Luz (ORCID: https://orcid.org/0000-0002-0575-5635)
- Hongqian Guo (ORCID: https://orcid.org/0000-0001-7243-667X)
- Shian‐Shiang Wang
- Bhalchandra Kashyapi
- Boxin Xue (ORCID: https://orcid.org/0000-0002-9996-2298)
- Yurii Golovko
- Lulin Ma (ORCID: https://orcid.org/0000-0003-2141-9348)
- Javier Domínguez Cruzat
- Pamela Salman Boghikian
- Ginil Kumar Pooleri (ORCID: https://orcid.org/0000-0002-7090-7885)
- Conrad Jacobs
- R. V. Smirnov (ORCID: https://orcid.org/0000-0001-6207-680X)
- Vineet Kwatra (ORCID: https://orcid.org/0000-0002-0912-4056)
- Pamela Jeyaraj
- Rafael Antonio Medina López (ORCID: https://orcid.org/0000-0002-4514-4329)
- Sufia Safina (ORCID: https://orcid.org/0000-0002-5309-8406)
- Lie Li (ORCID: https://orcid.org/0000-0003-1508-5484)
- Shailesh Bondarde
- М. I. Shkolnik (ORCID: https://orcid.org/0000-0003-0589-7999)
- Vinod Ganju (ORCID: https://orcid.org/0000-0003-4713-7752)
- Biswajit Dubashi (ORCID: https://orcid.org/0000-0001-9852-2525)
- Suresh G. Advani (ORCID: https://orcid.org/0000-0002-2670-903X)
- Igor Bondarenko (ORCID: https://orcid.org/0000-0002-7071-2471)
- Bernardo Herrera‐Imbroda (ORCID: https://orcid.org/0000-0002-6235-4897)
- Pai-Fu Wang
- Petro Ivashchenko
- Nianzeng Xing
- Francis V. James (ORCID: https://orcid.org/0000-0002-0556-4492)
- Zejun Yan (ORCID: https://orcid.org/0000-0002-8138-459X)
- Mareks Vejins
- Fabio Leite Couto Fernandez
- Guowei Shi (ORCID: https://orcid.org/0000-0002-2190-4880)
- Antonio Franco (ORCID: https://orcid.org/0000-0001-6773-3848)
- Yana Chapko
- Rajnish Nagarkar (ORCID: https://orcid.org/0000-0002-8045-842X)
- Lucas Nogueira (ORCID: https://orcid.org/0000-0002-3612-6524)
- Manasi Shah
- Ariel Osvaldo Zwenger
- Marcelo Garrido Salvo
- Chun-xi Wang (ORCID: https://orcid.org/0000-0002-5771-4755)
- Andrea Juliana Gomes (ORCID: https://orcid.org/0000-0001-7388-663X)
- Shaozhong Wei
- Felipe José Silva Melo Cruz (ORCID: https://orcid.org/0000-0002-4558-4850)
- Denis Kholtobin (ORCID: https://orcid.org/0000-0001-6645-6455)
- Rustem Gafanov (ORCID: https://orcid.org/0000-0002-7592-0392)
- M. Jakubovskis
- Ravimohan S. Mavuduru (ORCID: https://orcid.org/0000-0003-1369-7479)
- Alexey Plekhanov
- Albertas Ulys (ORCID: https://orcid.org/0000-0002-6613-0049)
- Iris Kuss
- Tongzu Liu
- Howard Gurney (ORCID: https://orcid.org/0000-0003-0217-5261)
- Jacques Malan (ORCID: https://orcid.org/0009-0002-4001-1612)
- Daniel D’Almeida Preto (ORCID: https://orcid.org/0000-0002-6561-7322)
- V. M. Paramonov
- Andrew Weickhardt (ORCID: https://orcid.org/0000-0002-6482-9681)
- Jitao Wu (ORCID: https://orcid.org/0000-0002-7924-3923)
- Vagif Atduev (ORCID: https://orcid.org/0000-0003-4478-7282)
- Павел Игоревич Скопин (ORCID: https://orcid.org/0000-0001-6662-5052)
- Michael Holmes (ORCID: https://orcid.org/0000-0003-4574-5738)
- Dongwen Wang (ORCID: https://orcid.org/0000-0002-6805-780X)
- Alan A. Azambuja
- Alexandr V. Zyryanov
- Julian Kim
- Raimundas Venckus
- Flavio Mavignier Cárcano (ORCID: https://orcid.org/0000-0002-0002-3507)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- G. Kenneth Jansz
- O. Gampel
- Xiaolin Wang
- Cheng Fu
- Mindaugas Jievaltas (ORCID: https://orcid.org/0000-0001-6726-8341)
- Kevin Bax (ORCID: https://orcid.org/0000-0002-5775-2356)
- Alexander Filippov (ORCID: https://orcid.org/0009-0005-8265-4642)
- A. Želvys (ORCID: https://orcid.org/0000-0002-9778-9372)
- Katsuki Arima Tiscoski (ORCID: https://orcid.org/0000-0003-0074-4272)
- Kahina Chabane
- Sanjeev Sewak
- Isabella Testa
- Oleg Gladkov
- Sujoy Gupta (ORCID: https://orcid.org/0000-0002-2226-4977)
- Борис Каспаров (ORCID: https://orcid.org/0000-0003-0341-3823)
- V. Lietuvietis (ORCID: https://orcid.org/0000-0002-0619-3910)
- David Olmos (ORCID: https://orcid.org/0000-0002-7003-4826)
- Alejandro Figueroa Torrejon
- Pawan Agarwal (ORCID: https://orcid.org/0000-0002-9031-8690)
- Amit Joshi (ORCID: https://orcid.org/0000-0003-4561-6135)
- Christian Caglevic Medina
- А. П. Лыков (ORCID: https://orcid.org/0000-0003-4897-8676)
- Augusto César de Andrade Mota (ORCID: https://orcid.org/0000-0002-4398-2708)
- Yu-Chin Tsai (ORCID: https://orcid.org/0009-0008-0773-6762)
- Carlos Eugênio Escovar
- Juliana de Menezes
- А. В. Султанбаев (ORCID: https://orcid.org/0000-0003-0996-5995)
- Amanda Gwendolyn Stevanovic
- Thamsanqa Madlala
- Evgeny Kopyltsov
- Ashwin Philips
- Chandan Jyoti Das (ORCID: https://orcid.org/0000-0001-6505-5940)
- Liina Nevalaita (ORCID: https://orcid.org/0000-0003-3752-1873)
- Adriano Augusto Peclat de Paula (ORCID: https://orcid.org/0000-0002-5916-0784)
- Neal D. Shore (ORCID: https://orcid.org/0000-0001-5767-0548)
- Suman Kalyan
- Vikram Prabha
- Alvin Tan
- Timur Andabekov
- Sophie Mathijs
- Haowen Jiang (ORCID: https://orcid.org/0000-0002-5349-1363)
- Liping Xie (ORCID: https://orcid.org/0000-0001-5041-3100)
- Shaogang Wang (ORCID: https://orcid.org/0000-0002-3206-1495)
- Ye Tian (ORCID: https://orcid.org/0000-0003-3931-6427)
- Julian Sanchez (ORCID: https://orcid.org/0000-0002-7198-839X)
- Jun Xiao (ORCID: https://orcid.org/0000-0002-6142-9914)
- Pamela Salman (ORCID: https://orcid.org/0000-0003-4389-8124)
- Andrey Semenov
- Laurence E. Krieger (ORCID: https://orcid.org/0000-0002-6894-6041)
- Qiu Ming-xing (ORCID: https://orcid.org/0000-0002-4685-199X)
- Ben Wan (ORCID: https://orcid.org/0000-0001-8388-0215)
- J.L. Álvarez-Ossorio Fernández
- Carlos Manuel Morante Deza
- Ekaterina Solovyeva
- Jun Qi
- M. O. Zavyalov
- Kunhi Parambath Haresh
- Naveen Ravel
- Marina Nechaeva
- Niraj Bhatt
- Corlia Coetzee
- SarojKumar Das Majumdar
- Krishna Kumar Rathnam
- Zhenhua Liu
- Peter Gilling
- Hsiao‐Jen Chung
- Josep María Gaya Sopena
- Weiqing Han
- Enrique Gallardo Díaz
- Mateus Gonçalves Costa (ORCID: https://orcid.org/0009-0005-3107-1121)
- Ghanashyam Biswas (ORCID: https://orcid.org/0000-0002-4855-9343)
- Shusuan Jiang
- Song Zheng (ORCID: https://orcid.org/0000-0002-8179-5954)
- Zhixian Yu
- Junhui Jiang
- Natalya Fadeeva
- Keji Xie
- Harsha P. Panchal
- Marie-Aude Le Berre
- Raghunath Krishnappa
- Shu‐Pin Huang
- Alexandre C. Sant'Anna
- Kunhi Parambath Haresh
- Fangjian Zhou
- Balaji Reddy (ORCID: https://orcid.org/0009-0005-8904-0707)
- Pedro Arroyo
- C. Llorente Abarca (ORCID: https://orcid.org/0009-0005-4562-3281)
- Pablo Borrega García
- Jonathan Giddens
- Gisele Marinho dos Santos
- Ashish Kaushal
- Charles Andreé Joseph de Pádua
- Andrejs Aleksandrovs
- Gourav Parkash
- Alvis Laukmanis
- Paul Quellette
- George Vrabec
- Alejandro Acevedo Gaete
- Yasna Daniela Valenzuela Velasquez
- Anibal Salazar Huerta
Institutions
- Lithuanian University of Health Sciences (LT)
- Central South University (CN)
- Vilnius University (LT)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Budgetary Health Care Institution of the Omsk Region "Clinical Oncology Center" (RU)
- Riga East University Hospital (LV)
- Pauls Stradiņš Clinical University Hospital (LV)
- Hospital Universitario 12 De Octubre (ES)
- Hunan Cancer Hospital (CN)
- Orion Corporation (Finland) (FI)
- Bayer (Italy) (IT)
- Centre Hospitalier de l’Université de Montréal (CA)
- National Cancer Institute (LT)
- Carolina Urologic Research Center (US)
- Bayer (France) (FR)
- All India Institute of Medical Sciences (IN)
- Bayer (Germany) (DE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1200/jco-24-01798
- Citations
- 113
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 47.34