Chemical constituents from the endophytic fungus <i>Aspergillus</i> sp. S3 of <i>Hibiscus tiliaceus</i>
A new sterol, aspersterol E (<b>1</b>), a newly discovered alkaloid, asperginine A (<b>2</b>), and five known compounds (<b>3-7</b>) were obtained from the endophytic fungus <i>Aspergillus</i> sp. S3 of <i>Hibiscus tiliaceus</i> Linn. The compounds were extracted from their fermentation products using silica gel, ODS C18, and semi-preparative HPLC. The structure of each compound was determined through spectroscopic analysis. All the obtained compounds (<b>1-7</b>) were evaluated for their cytotoxic activity against the mouse pre-gastric cancer cell line MFC by using the MTT assay. The IC<sub>50</sub> values of compounds <b>1</b>, <b>2</b>, <b>3,</b> and <b>5</b> were found to be 153.43 μM, 61.25 μM, 73.19 μM, and 181.69 μM respectively.
Authors
- Chunmei Yang
- Mengmeng Wang (ORCID: https://orcid.org/0000-0002-2850-6092)
- Wenfeng Chen (ORCID: https://orcid.org/0000-0001-5259-7214)
- Jing Tian (ORCID: https://orcid.org/0000-0002-7559-0258)
- Yanan Lu (ORCID: https://orcid.org/0000-0002-7555-4337)
- Liang Hanqiao
- Bo-Heng Hu
- Ruizhang Feng
Institutions
- Beijing Tongren Hospital (CN)
- Institute for Biomedicine (IT)
- Yibin University (CN)
- Crest Middle School (US)
- Beijing City University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1080/10286020.2024.2399572
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.34