[Maternal <i>MTR</i> gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects].
Maternal <i>MTR</i> gene polymorphisms significantly correlate with the incidence of VSD in offspring. Mothers with variations at rs6668344 can decrease the susceptibility to VSD in their offspring by supplementing with folic acid during the periconceptional period, suggesting the importance of periconceptional folic acid supplementation in genetically at-risk populations to prevent VSD in offspring.
Authors
- Hanjun Liu (ORCID: https://orcid.org/0000-0003-1466-4193)
- Jianhui Wei (ORCID: https://orcid.org/0000-0001-6849-552X)
- Jiabi Qin (ORCID: https://orcid.org/0000-0002-9360-4991)
- Manjun Luo
- Liuxuan Li
- Mengting Sun (ORCID: https://orcid.org/0000-0002-8517-8451)
- Xiaorui Ruan
- Jia-Peng Tang
Institutions
- Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-13
- DOI
- https://doi.org/10.7499/j.issn.1008-8830.2403067
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article