Genetic variants associated with white blood cell count amongst individuals with sickle cell disease
Genetics plays an important role in regulating WBC count in patients with SCD. Our results point to possible mechanisms involved in WBC count variation and as increased WBC count is associated with more severe SCD, these results could suggest potential therapeutic targets for individuals with SCD.
Authors
- Shannon Kelly (ORCID: https://orcid.org/0000-0003-2049-3992)
- Miriam V. Flor‐Park (ORCID: https://orcid.org/0000-0001-5558-6166)
- Mina Cintho Ozahata (ORCID: https://orcid.org/0000-0002-1272-2380)
- André Rolim Belisário (ORCID: https://orcid.org/0000-0003-0166-4258)
- Carla Luana Dinardo (ORCID: https://orcid.org/0000-0002-0453-7863)
- Grier P. Page (ORCID: https://orcid.org/0000-0003-2582-3786)
- Brian Custer (ORCID: https://orcid.org/0000-0001-6251-366X)
- Dahra Teles
- Yuelong Guo (ORCID: https://orcid.org/0000-0003-1287-1906)
- Éster Cerdeira Sabino (ORCID: https://orcid.org/0000-0003-2623-5126)
- Isabel Cristina Gomes (ORCID: https://orcid.org/0000-0002-5549-3426)
- Luiz Amorim
- Barbara Malta
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- RTI International (US)
- Pacific Research Institute (US)
- Hemorio (BR)
- Vitalant (US)
- UCSF Benioff Children's Hospital (US)
- Fundação Hemopa (BR)
- Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (BR)
- Fundação Pró-Sangue Hemocentro de São Paulo (BR)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1111/bjh.19758
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- RTI International
- National Institutes of Health
- University of California, San Francisco
- National Heart, Lung, and Blood Institute