Evaluating RB1 and p53 as diagnostic markers in treatment‐related neuroendocrine prostate cancer through immunohistochemistry and genomic analysis of <i>RB1</i> and <i>TP53</i>
This study indicated high concordance between IHC and NGS findings for RB1/RB1 and p53/TP53 in t-NEPC. We provide a comprehensive benchmark of NGS performance compared with IHC, and these findings may help increase the diagnostic sensitivity of t-NEPC.
Authors
- Hideto Ueki (ORCID: https://orcid.org/0000-0002-7742-4528)
- Naoto Wakita (ORCID: https://orcid.org/0009-0007-1353-7789)
- Junichiro Hirata
- Yukari Bando (ORCID: https://orcid.org/0000-0001-7736-1216)
- Naoe Jimbo (ORCID: https://orcid.org/0000-0003-0423-3568)
- Yuzo Nakano (ORCID: https://orcid.org/0000-0002-0029-0023)
- Takuto Hara (ORCID: https://orcid.org/0000-0003-4524-2815)
- Taisuke Tobe (ORCID: https://orcid.org/0000-0001-9289-9014)
- Tomoaki Terakawa (ORCID: https://orcid.org/0000-0002-4447-6516)
- Yasuyoshi Okamura (ORCID: https://orcid.org/0000-0002-8466-3949)
- Koji Chiba (ORCID: https://orcid.org/0000-0001-5575-0667)
- Kotaro Suzuki (ORCID: https://orcid.org/0000-0003-4589-9251)
- Jun Teishima (ORCID: https://orcid.org/0000-0001-8429-1607)
- Hideaki Miyake
Institutions
- Kobe University (JP)
Publication Details
- Journal
- The Prostate
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1002/pros.24791
- Citations
- 5
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09