Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas
Multiple orthogonal approaches demonstrate that <i>Kras</i> <sup>G12D</sup> and <i>Gnas</i> <sup>R201C</sup> co-expression results in a gene signature of gastric pyloric metaplasia and glycolytic dependency during IPMN pathogenesis. The observed metabolic reprogramming may provide a potential target for therapeutics and interception of IPMNs.
Authors
- Merve Dede (ORCID: https://orcid.org/0000-0002-0868-5863)
- Lotfi Abou‐Elkacem (ORCID: https://orcid.org/0000-0001-8657-9030)
- Paytience Smith
- Traver Hart (ORCID: https://orcid.org/0000-0002-1880-3341)
- Pratip K. Bhattacharya (ORCID: https://orcid.org/0000-0002-0625-252X)
- Fredrik I. Thege (ORCID: https://orcid.org/0000-0002-1822-4526)
- Michael P. Kim (ORCID: https://orcid.org/0000-0002-8269-854X)
- Kimal Rajapakshe (ORCID: https://orcid.org/0000-0002-0472-858X)
- Anirban Maitra (ORCID: https://orcid.org/0000-0001-7923-9978)
- Yuki Makino (ORCID: https://orcid.org/0000-0002-2690-4548)
- Kenjiro Date (ORCID: https://orcid.org/0000-0003-0376-1000)
- Benson Chellakkan Selvanesan (ORCID: https://orcid.org/0000-0001-8013-1294)
- Nathaniel Yee
- Marta Sans (ORCID: https://orcid.org/0000-0002-7756-5101)
- Jimin Min (ORCID: https://orcid.org/0000-0002-2309-7875)
- Prasanta Dutta (ORCID: https://orcid.org/0000-0002-9887-6507)
- Megan J. Siemann (ORCID: https://orcid.org/0000-0001-8501-2366)
- Akiko Sagara (ORCID: https://orcid.org/0000-0001-9325-1367)
- José S. Enriquez (ORCID: https://orcid.org/0000-0002-9119-8176)
- Takashi Okumura
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Gujarat Cancer & Research Institute (IN)
- Anesthesiology and Surgical Oncology Research Group (US)
- Center for Translational Molecular Medicine (NL)
- Children's Cancer Center (US)
Publication Details
- Journal
- Gut
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1136/gutjnl-2024-332412
- Citations
- 9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- Khalifa Bin Zayed Al Nahyan Foundation
- University of Texas MD Anderson Cancer Center
- Japan Society for the Promotion of Science
- National Cancer Institute