Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity
We have succeeded in synthesizing novel tropane hybrids exhibiting significant anti-Hsp90 action, similar to XL888 analogues.
Authors
- Hanadi Y. Medrasi
- Thoraya A. Farghaly (ORCID: https://orcid.org/0000-0002-9620-8548)
- Eman M. H. Abbas (ORCID: https://orcid.org/0000-0002-2407-4819)
- Rehab Sabour (ORCID: https://orcid.org/0000-0002-3390-444X)
- Asmaa F. Kassem (ORCID: https://orcid.org/0000-0001-9020-9956)
- Norah A Alsaiari
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Cairo University (EG)
- Al-Azhar University (EG)
- Umm al-Qura University (SA)
- University of Jeddah (SA)
- National Research Centre (EG)
- Najran University (SA)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-09-16
- DOI
- https://doi.org/10.2174/0109298673313163240829094557
- Citations
- 2
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.47