Hypoxia Promotes the Expression of <scp>ADAM9</scp> by Tubular Epithelial Cells, Which Enhances Transforming Growth Factor β1 Activation and Promotes Tissue Fibrosis in Patients With Lupus Nephritis
Hypoxia promotes the expression of ADAM9 by TECs, which is responsible for the development of interstitial fibrosis in patients with LN by enhancing the TGFβ1 activation, which promotes fibroblasts to produce collagen and α-SMA.
Authors
- Theodoros Vichos (ORCID: https://orcid.org/0009-0002-7237-1954)
- Caroline Ann Owen (ORCID: https://orcid.org/0000-0003-4377-3591)
- Reza Abdi (ORCID: https://orcid.org/0000-0003-4789-5422)
- George C. Tsokos (ORCID: https://orcid.org/0000-0001-9589-2360)
- Masataka Umeda (ORCID: https://orcid.org/0000-0002-6647-7130)
- Kunihiro Ichinose (ORCID: https://orcid.org/0000-0001-8794-7106)
- Kohei Karino (ORCID: https://orcid.org/0000-0001-5319-3174)
- Ryo Hisada (ORCID: https://orcid.org/0000-0002-4225-1639)
- Abhigyan Satyam (ORCID: https://orcid.org/0000-0001-9838-4572)
- Kenta Torigoe (ORCID: https://orcid.org/0000-0003-3085-0391)
- Rhea Bhargava (ORCID: https://orcid.org/0000-0001-6238-8627)
- Tomoya Nishino (ORCID: https://orcid.org/0000-0002-6270-3655)
- Takahiro Maeda (ORCID: https://orcid.org/0000-0003-4479-7835)
- Atsushi Kawakami (ORCID: https://orcid.org/0000-0002-1512-8782)
- Takashi Igawa
- Nobuya Yoshida
- Ana Laura Fischer Kunzler (ORCID: https://orcid.org/0009-0004-0976-5779)
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Shimane University (JP)
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/art.42987
- Citations
- 4
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Gilead Sciences
- National Institutes of Health