Oxidized Polyunsaturated Fatty Acid Promotes Colitis and Colitis-Associated Tumorigenesis in Mice
These results support that oxidized PUFA promotes the development of colitis and associated tumorigenesis in mouse models via TLR4- and gut microbiota-dependent mechanisms. Our findings highlight the potential need to update regulation policies and industrial standards for oxidized PUFA levels in food.
Authors
- Yuxin Wang (ORCID: https://orcid.org/0000-0002-0305-9820)
- Heather L. Sherman
- Eric A. Decker (ORCID: https://orcid.org/0000-0002-5159-4123)
- Haixia Yang (ORCID: https://orcid.org/0000-0002-4410-9257)
- Ipek Bayram (ORCID: https://orcid.org/0000-0002-6604-6525)
- Katherine Z. Sanidad (ORCID: https://orcid.org/0000-0002-2689-3826)
- Yige Wang (ORCID: https://orcid.org/0000-0002-8189-192X)
- Renhua Song (ORCID: https://orcid.org/0000-0002-8228-7281)
- David Johnson (ORCID: https://orcid.org/0000-0002-2323-6847)
- Quancai Sun (ORCID: https://orcid.org/0000-0002-9171-269X)
- Lisa M. Minter (ORCID: https://orcid.org/0000-0002-1728-6389)
- Justin Wong (ORCID: https://orcid.org/0000-0002-7038-5079)
- Weicang Wang (ORCID: https://orcid.org/0000-0002-2722-507X)
- Daeyoung Kim (ORCID: https://orcid.org/0000-0002-2223-2166)
- Guodong Zhang (ORCID: https://orcid.org/0000-0001-7780-5470)
- Jianan Zhang (ORCID: https://orcid.org/0000-0001-9801-2779)
- Wenqi Yang
- Melody Y. Zeng (ORCID: https://orcid.org/0000-0002-0031-4267)
Institutions
- Florida State University (US)
- The University of Sydney (AU)
- Cornell University (US)
- Purdue University West Lafayette (US)
- University of Massachusetts Amherst (US)
- Centenary Institute (AU)
- Weill Cornell Medicine (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae148
- Citations
- 11
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- U.S. Department of Agriculture
- National Institutes of Health
- National Institute of Food and Agriculture