<scp>TLR7</scp>/8 Activation in Immune Cells and Muscle by <scp>RNA</scp>‐Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis
Our results suggest that patients with IIMs have autoantibodies in their blood causing TLR7/8 activation, which leads to inflammation in muscles with potential deleterious effects.
Authors
- Nicholas Geraci (ORCID: https://orcid.org/0000-0003-4294-9188)
- Mark A. Jensen (ORCID: https://orcid.org/0000-0001-7081-8586)
- Petra Budde (ORCID: https://orcid.org/0000-0001-8991-3495)
- Kavita Y. Sarin (ORCID: https://orcid.org/0000-0001-5363-3053)
- David Fiorentino (ORCID: https://orcid.org/0000-0001-7951-3674)
- Irina Kalatskaya (ORCID: https://orcid.org/0000-0002-1663-859X)
- Timothy B. Niewold (ORCID: https://orcid.org/0000-0003-3532-6660)
- Andrew T. Bender (ORCID: https://orcid.org/0000-0003-4349-4488)
- Aditee Deshpande
- Vera Sellers
- Phanindra Velisetty
- Fatima Strand
- Yin Wu
- Carmina Bhavsar
- Chia‐Chi Sun
Institutions
- Hospital for Special Surgery (US)
- Ono Pharmaceutical (United States) (US)
- Emergency University (US)
- United Therapeutics (United States) (US)
- Merck Serono S.p.A. (Italy) (IT)
- Stanford University (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/art.42989
- Citations
- 10
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- Massachusetts General Hospital
- York University
- NYU Grossman School of Medicine