A Molecular Dynamic Simulation, Structural Analysis, and Ex Vivo Insights into the P-glycoprotein Mediated Interactions of Dietary Polyphenols with Cyclin-dependent Kinase Inhibitors: A Potential Strategy to Counteract Drug Efflux
The study emphasizes the significance of curcumin and quercetin as inhibitors of P-glycoprotein, demonstrating their potential to decrease the efflux of palbociclib and ribociclib, consequently contributing to their bioavailability enhancement.
Authors
- Krishnamurthy Bhat (ORCID: https://orcid.org/0000-0002-8604-472X)
- Jagadish Puralae Channabasavaiah
- Sai Krishna Anand Vullendula
- Mrunal Desai (ORCID: https://orcid.org/0000-0002-0376-6082)
- Prajakta Patil (ORCID: https://orcid.org/0000-0001-5382-1716)
- Swapnil J. Dengale (ORCID: https://orcid.org/0000-0002-0013-5007)
- Gautham G. Shenoy (ORCID: https://orcid.org/0000-0002-1312-6257)
- Rajdeep Ray (ORCID: https://orcid.org/0000-0001-8526-8580)
Institutions
- Manipal Academy of Higher Education (IN)
- National Institute of Pharmaceutical Education and Research (IN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-09-16
- DOI
- https://doi.org/10.2174/0109298673319832240829164046
- Citations
- 3
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Manipal Academy of Higher Education