Chronic Activation of Tubulin Tyrosination Improves Heart Function
This study provides the first proof of concept that chronic activation of tubulin tyrosination in HCM mice and in human EHTs improves heart function and holds promise for targeting the nonsarcomeric cytoskeleton in heart disease.
Authors
- Birgit Geertz
- Christina Y. Chen (ORCID: https://orcid.org/0000-0002-3244-3477)
- Jolanda van der Velden (ORCID: https://orcid.org/0000-0001-5224-5788)
- Ingke Braren (ORCID: https://orcid.org/0000-0002-5676-9850)
- Giulia Mearini
- Diana Lindner (ORCID: https://orcid.org/0000-0001-5477-769X)
- Benjamin L. Prosser (ORCID: https://orcid.org/0000-0003-3696-9131)
- Niels Pietsch (ORCID: https://orcid.org/0000-0002-9990-9817)
- Hartmut Schlüter (ORCID: https://orcid.org/0000-0002-9358-7036)
- Lucie Carrier (ORCID: https://orcid.org/0000-0001-8776-5820)
- Saskia Schlossarek
- Bente Siebels (ORCID: https://orcid.org/0000-0001-9183-0381)
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Matthew A. Caporizzo (ORCID: https://orcid.org/0000-0002-9997-5718)
- Lucas Bacmeister (ORCID: https://orcid.org/0000-0001-8240-2270)
- Hannah Voß (ORCID: https://orcid.org/0000-0002-0900-7183)
- Marisol Herrera-Rivero (ORCID: https://orcid.org/0000-0001-7064-9487)
- Svenja Kupsch
- Elisabeth Krämer
Institutions
- University of Vermont (US)
- Universität Hamburg (DE)
- University of Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute of Human Genetics (PL)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1161/circresaha.124.324387
- Citations
- 22
- Primary Topic
- Electron Spin Resonance Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.57
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Fondation Leducq
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- Universitätsklinikum Hamburg-Eppendorf