Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation

Cerebral infarction, the blockage of blood vessels in the brain, is generally an age-related illness. Factors such as unhealthy diets, stressful behaviours and decreased environmental consistency with physiological barriers also contribute to increased casualties. Long-term brain function reconstruction and successful drug therapy are needed. The most frequent malignant brain tumour, glioblastoma, has been linked to variations in mitochondrial ROS, chaperone-mediated autophagy, and the interaction between lncRNA (BC200) and miRNA. Glioblastoma stem cells express high levels of ATP/P2X7 receptors, promoting survival by activating M2 muscarinic receptors. This expert opinion provides an overview of the latest experimental drug therapies aimed at protecting against and restoring cerebral stroke. Nanomedicine overcomes the challenges associated with traditional therapy and physiological obstacles in the treatment of cerebral infarction by improving stroke management, including diagnosis, imaging, and treatment, addressing a diverse range of associated factors.

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Publication Details

Journal
Current Medicinal Chemistry
Published
2024-09-16
DOI
https://doi.org/10.2174/0109298673306668240829144324
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation

Jonathan A. Lal, Fahad A. Al‐Abbasi, Vikas Kumar, Firoz Anwar
Current Medicinal Chemistry
Nanoparticle-Based Drug Delivery
article

Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation

Jonathan A. Lal, Fahad A. Al‐Abbasi, Vikas Kumar, Firoz Anwar
article en

Abstract

Cerebral infarction, the blockage of blood vessels in the brain, is generally an age-related illness. Factors such as unhealthy diets, stressful behaviours and decreased environmental consistency with physiological barriers also contribute to increased casualties. Long-term brain function reconstruction and successful drug therapy are needed. The most frequent malignant brain tumour, glioblastoma, has been linked to variations in mitochondrial ROS, chaperone-mediated autophagy, and the interaction between lncRNA (BC200) and miRNA. Glioblastoma stem cells express high levels of ATP/P2X7 receptors, promoting survival by activating M2 muscarinic receptors. This expert opinion provides an overview of the latest experimental drug therapies aimed at protecting against and restoring cerebral stroke. Nanomedicine overcomes the challenges associated with traditional therapy and physiological obstacles in the treatment of cerebral infarction by improving stroke management, including diagnosis, imaging, and treatment, addressing a diverse range of associated factors.

Current Medicinal ChemistryVol. 32(27)
King Abdulaziz University (SA), Sam Higginbottom Institute of Agriculture (IN)
Good health and well-being
Openalex Percentile: Top 93%
Nanoparticle-Based Drug Delivery
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