Paternal undernutrition and overnutrition modify semen composition and preimplantation embryo developmental kinetics in mice
Our current study shows that paternal nutritional status has the potential to influence male metabolic and reproductive health, impacting on embryonic development and the maternal reproductive tract. This study highlights potential direct (sperm-mediated) and indirect (seminal vesicle fluid-mediated) pathways in which a father's poor diet could shape the long-term health of his offspring.
Authors
- Adam J. Watkins (ORCID: https://orcid.org/0000-0002-0842-1251)
- Nadine Holmes (ORCID: https://orcid.org/0000-0001-7470-3786)
- Sonal Henson (ORCID: https://orcid.org/0000-0002-2002-5462)
- Donna O’Neil
- Catherine Winder (ORCID: https://orcid.org/0000-0002-1648-5255)
- David J. Boocock (ORCID: https://orcid.org/0000-0002-7333-3549)
- Victoria Wright (ORCID: https://orcid.org/0000-0001-7826-1516)
- N.S. Eid (ORCID: https://orcid.org/0000-0001-8968-0986)
- Hannah L. Morgan (ORCID: https://orcid.org/0000-0002-6233-2989)
- Clare Coveney (ORCID: https://orcid.org/0000-0001-7047-6408)
- Warwick B. Dunn (ORCID: https://orcid.org/0000-0001-6924-0027)
Institutions
- University of Nottingham (GB)
- Queen's Medical Centre (GB)
- Nottingham Trent University (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12915-024-01992-0
- Citations
- 13
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 14.42
Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council