Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin
Our recurrent OT cases had deviations in lymphocyte maturation and IFN-γ responses possibly caused by genetic reasons. However, limitations of our study include failure to identify uniform genetic mechanisms. In addition, we cannot rule out the possibility that the immunological abnormalities can be triggered by chronic toxoplasmosis. Despite the limitations, our findings contribute to the understanding of ocular immunity and development of recurrent OT.
Authors
- Teija Paakkola (ORCID: https://orcid.org/0000-0003-4788-5822)
- Mira Siiskonen
- Katri Pylkäs (ORCID: https://orcid.org/0000-0002-2449-0521)
- Nina Hautala (ORCID: https://orcid.org/0000-0001-5454-5602)
- K Kettunen (ORCID: https://orcid.org/0000-0001-7402-461X)
- Virpi Glumoff (ORCID: https://orcid.org/0000-0003-3461-6471)
- Janna Saarela (ORCID: https://orcid.org/0000-0002-0853-6219)
- Timo Hautala (ORCID: https://orcid.org/0000-0001-7889-1614)
- Zhi Jane Chen (ORCID: https://orcid.org/0000-0002-4658-7463)
- Maija Joensuu
Institutions
- University of Helsinki (FI)
- University of Oslo (NO)
- Oulu University Hospital (FI)
- NordLab (FI)
- Institute for Molecular Medicine Finland (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- Oulu University of Applied Sciences (FI)
- University of Oulu (FI)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/bmjophth-2024-001769
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00