Systemic Lupus Erythematosus: Clinical Manifestations, Medical Management, and Dental Treatment Modifications.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that varies in clinical presentation and disease course. SLE has a strong female predilection and is more common in certain racial groups than others. There is no single set of universally accepted diagnostic criteria for SLE, which can make the disease challenging to diagnose. The disorder has the potential to affect nearly every organ system in the body, including the oral cavity. A complete understanding of the etiology and pathophysiology of SLE continues to evade the medical profession; however, advances in this area of research have drastically improved the quality of life of SLE patients. There currently is no cure for this condition, so present-day therapies aim to control patient symptoms and reduce SLE flare-ups. This article discusses the pathophysiology, diagnosis, oral and systemic manifestations, therapeutic interventions, and dental management of SLE patients.