RELATIONSHIP BETWEEN MODIFIED SYSTEMIC IMMUNE-INFLAMMATION INDEX AND CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION ST Segment Yükselmeli Miyokard İnfarktüsü Olan Hastalarda Modifiye Sistemik İmmün İnflamasyo

ABSTRACTObjective: Developing contrast induced nephropathy after primary PCI in patients with ST segment elevationmyocardial infarction is a risky condition in terms of mortality and morbidity. Various studies have shownthat the systemic inflammatory index predicts (SII) the development of CIN. Mean platelet volume (MPV)is an important indicator known to be associated with the platelet function and activation. Therefore, werevised SII and named it modified SII (mSII) by using NLR multiply MPV.Material and Methods: This study includes patients who underwent pPCI due to STEMI in our cardiologydepartment between February 2015 and February 2021. Modified SII was obtained by using MPV insteadof platelet in the formula (mSII= NLR x MPV). Patients who underwent pPCI with STEMI were divided intotwo groups, those with CIN and those without CIN, and compared. Informed consent was obtained fromall patients.Results: In the logistic regression analysis, it was observed that the mSII, NLR, GFR and contrast mediumamount was independent predictor of CIN. The optimal threshold mSII for predicting CIN was >42.5, with a78.1% sensitivity and 52.3% specificity ([AUC]: 0.639, 95%CI: 0.602- 0.674, p< 0.001). Pairwise comparisonof ROC curves, it was observed that the predictive value of mSII for the development of CIN was better thanNLR. (z-test = 3.144, P = 0.001)Conclusion: We think that mSII, which we have shown to be superior to SII in predicting the developmentof CIN and is very easy to calculate, is a parameter that can be considered in predicting the development ofCIN after pPCI in STEMI patients.