Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

In June 2023, the American Society of Anesthesiologists issued guidelines recommending preoperative withholding of glucagon-like peptide 1 receptor agonists (GLP-1RAs), used for type diabetes management and weight loss. These guidelines, which have been questioned, arose from reports of delayed gastric emptying and pulmonary aspiration following induction of anesthesia in patients using GLP-1 RAs. Although preoperative medication guidelines can prevent complications,withholding medications can also result in adverse effects. Furthermore, associated logistical burdens can result in surgical cancellations, significant care delays, and financial losses from unused operating room time.