[Linarin inhibits microglia activation-mediated neuroinflammation and neuronal apoptosis in mouse spinal cord injury by inhibiting the TLR4/NF-κB pathway].
The neuroprotective effect of linarin is medicated by inhibition of microglia activation <i>via</i> suppressing the TLR4/NF‑κB signaling pathway, which mitigates neural inflammation and reduce neuronal apoptosis to enhance motor function of the SCI mice.
Authors
- Jianguo Hu (ORCID: https://orcid.org/0000-0002-9055-874X)
- Yaling Xu (ORCID: https://orcid.org/0000-0001-6503-930X)
- Xiao‐Xin Yan (ORCID: https://orcid.org/0000-0001-6654-982X)
- Tao Duan (ORCID: https://orcid.org/0000-0001-5320-4611)
- Lijun Xu (ORCID: https://orcid.org/0000-0001-7352-2086)
- Yang Sun (ORCID: https://orcid.org/0000-0002-6857-8437)
- Yi‐Lang Chen (ORCID: https://orcid.org/0000-0002-1292-0758)
- Yi Xia (ORCID: https://orcid.org/0000-0002-2838-2552)
- L Xiao
Institutions
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-08-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.08.18
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
Funders
- National Natural Science Foundation of China