[Pharmacodynamics of <i>Qingxin Jieyu</i> Granules for treatment of atherosclerosis and its regulatory mechanism for lipid metabolism].
QXJYG alleviates lipid metabolism disorder and improves histopathological changes of the abdominal aorta of AS rats possibly by lowering ox-LDL level, reducing LOX-1 expression, activating PPAR<i>γ</i> and RXR<i>α</i>, and inhibiting P65 phosphorylation to reduce VCAM-1 and ICAM-1 expression in the aorta.
Authors
- Qingqing Cai (ORCID: https://orcid.org/0000-0001-9875-2419)
- Sen-Yu Zhang
- L Zhang
- Kanhua Yin (ORCID: https://orcid.org/0000-0002-4769-3129)
- Z Gao (ORCID: https://orcid.org/0000-0002-6255-141X)
- Jin Chu (ORCID: https://orcid.org/0000-0003-4606-6585)
- Chunqing He (ORCID: https://orcid.org/0000-0001-6439-4094)
- Jianxun Qi (ORCID: https://orcid.org/0000-0002-9358-4732)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-08-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2024.08.10
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article