Ameliorated cellular hallmarks of myotonic dystrophy in hybrid myotubes from patient and unaffected donor cells
Fusion of only a limited number of unaffected myogenic precursors to DM1 myotubes already ameliorates cellular disease hallmarks, offering promise for the development of cell transplantation strategies to lower disease burden.
Authors
- Derick G. Wansink (ORCID: https://orcid.org/0000-0002-6773-8662)
- Hans van Bokhoven (ORCID: https://orcid.org/0000-0002-2153-9254)
- Renée H.L. Raaijmakers (ORCID: https://orcid.org/0000-0001-9495-4830)
- Darren G. Monckton (ORCID: https://orcid.org/0000-0002-8298-8264)
- C. Rosanne M. Ausems (ORCID: https://orcid.org/0000-0002-6467-1984)
- Marieke Willemse
- Baziel G.M. van Engelen (ORCID: https://orcid.org/0000-0001-9867-9047)
- Sarah A. Cumming (ORCID: https://orcid.org/0000-0002-0201-3660)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- University of Glasgow (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s13287-024-03913-y
- Citations
- 2
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Radboud Universiteit
- Prinses Beatrix Spierfonds
- Radboud Universitair Medisch Centrum
- Stichting Spieren voor Spieren