Sex-related differences in efficacy of bone marrow-derived high aldehyde dehydrogenase activity cells against pulmonary fibrosis
Our results indicated that Lin<sup>-</sup>/ALDH<sup>br</sup> cell therapy could ameliorate pulmonary fibrosis by reducing oxidative stress and suggested that their efficacy was mediated by sex-related differences. Thus, sex-awareness strategies may be important for clinical application of bone marrow ALDH<sup>br</sup> cells as a therapeutic tool.
Authors
- Taku Nakashima (ORCID: https://orcid.org/0000-0002-0035-674X)
- Noboru Hattori (ORCID: https://orcid.org/0000-0002-8234-942X)
- Kakuhiro Yamaguchi (ORCID: https://orcid.org/0000-0002-9117-1934)
- Hiroshi Iwamoto (ORCID: https://orcid.org/0000-0003-4922-5334)
- Kiyofumi Shimoji (ORCID: https://orcid.org/0000-0001-5382-4730)
- Shinjiro Sakamoto (ORCID: https://orcid.org/0009-0009-3543-0813)
- Kazunori Fujitaka (ORCID: https://orcid.org/0000-0002-8686-551X)
- Takeshi Masuda (ORCID: https://orcid.org/0000-0003-3557-0049)
- Yasushi Horimasu (ORCID: https://orcid.org/0000-0002-3390-8491)
- Hironobu Hamada (ORCID: https://orcid.org/0000-0002-7979-0708)
- S Inada
Institutions
- Hiroshima University (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s13287-024-03933-8
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science