Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood
The metabolic landscape of human HSPCs at three developmental stages (FL, UCB, and aBM), combined with proteomics and functional validations, substantially extends our understanding of HSC metabolic regulation. These findings provide valuable resources for understanding human HSC function and development during fetal and adult life.
Authors
- Fei Liang
- Nan Liu (ORCID: https://orcid.org/0000-0001-8982-1582)
- Qianqian Wang (ORCID: https://orcid.org/0009-0003-4622-0199)
- Yuying Sun
- Hang Yu (ORCID: https://orcid.org/0000-0002-8869-6166)
- Yan Ju (ORCID: https://orcid.org/0000-0003-4588-0710)
- Ruiwen Fan
- Yang Zeng (ORCID: https://orcid.org/0000-0002-6718-9501)
- Hongyu Yin
- Qingxiang Hou
- Fudong Chen
- Xiao Zhao
- Yanyu Xiu
- Lihong Bian
- Mingfang Xiong
- Haoyu Yang
- Juan Long (ORCID: https://orcid.org/0009-0003-8567-2331)
Institutions
- Shanxi Agricultural University (CN)
- Chinese PLA General Hospital (CN)
- Air Force General Hospital PLA (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s13287-024-03930-x
- Citations
- 3
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- General Hospital of People’s Liberation Army
- Beijing Nova Program