A Pooled Analysis of Eight Clinical Studies Suggests a Link Between Influenza-Like Symptoms and Pharmacodynamics of the Toll-Like Receptor-7 Agonist Vesatolimod
Flu-like AEIs associated with vesatolimod administration were typically mild but increased with exposure, which may be predicted by the response to initial doses. The data suggest that adaptive clinical monitoring could help maximize pharmacodynamic responses and balance adverse events in future clinical trials of vesatolimod.
Authors
- Christiaan R. de Vries (ORCID: https://orcid.org/0000-0002-4667-5973)
- Sharon A. Riddler (ORCID: https://orcid.org/0000-0002-2545-7037)
- Devi SenGupta (ORCID: https://orcid.org/0000-0003-3811-8111)
- Yanhui Cai (ORCID: https://orcid.org/0009-0001-9936-8184)
- Cynthia Brinson (ORCID: https://orcid.org/0000-0002-3024-2815)
- Jeffrey J. Wallin (ORCID: https://orcid.org/0000-0002-5952-3813)
- Elena Vendrame (ORCID: https://orcid.org/0000-0002-5595-1773)
- Steven G. Deeks (ORCID: https://orcid.org/0000-0001-6371-747X)
- Moti N. Ramgopal (ORCID: https://orcid.org/0000-0001-7448-1976)
- Constance A. Benson (ORCID: https://orcid.org/0000-0002-3781-1347)
- Donovan Verrill
- Yanan Zheng
- Liao Zhang
- Edwin DeJesus
- Daina Lim (ORCID: https://orcid.org/0009-0007-5184-6339)
- Anthony Mills
- Michael F. Para
- Wendy Jiang
- Xiaopeng Liu
Institutions
- Midway University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- UC San Diego Health System (US)
- The Ohio State University Wexner Medical Center (US)
- Orlando Immunology Center (US)
- Public Health Foundation Enterprises (US)
- Gilead Sciences (United States) (US)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1007/s40121-024-01034-w
- Citations
- 4
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Gilead Sciences