Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin
Our results highlight remarkable intrinsic sex-differences and sex-specific response patterns towards pharmacological challenged podocyte homeostasis which might fundamentally contribute to sex differences in kidney disease susceptibilities and progression. This work provides rationale and an in-depth database for novel targets to be tested in specific kidney disease models to advance with sex-specific treatment strategies.
Authors
- Raphaela Fritsche‐Guenther (ORCID: https://orcid.org/0000-0002-6965-0226)
- Florian Grahammer (ORCID: https://orcid.org/0000-0002-7851-754X)
- Pinchao Wang (ORCID: https://orcid.org/0000-0002-1555-4693)
- Eric Blanc (ORCID: https://orcid.org/0000-0002-4369-0254)
- Muhammad Imtiaz Ashraf (ORCID: https://orcid.org/0000-0002-6789-5393)
- Markus Matthias Rinschen (ORCID: https://orcid.org/0000-0002-9252-1342)
- Sebastian Bachmann (ORCID: https://orcid.org/0000-0002-1234-6645)
- Dennis Gürgen (ORCID: https://orcid.org/0000-0001-9241-6537)
- Dieter Beule (ORCID: https://orcid.org/0000-0002-3284-0632)
- Jennifer Kirwan (ORCID: https://orcid.org/0000-0002-5423-1651)
- Nikolaus Rajewsky (ORCID: https://orcid.org/0000-0002-4785-4332)
- Hongfan Zhao (ORCID: https://orcid.org/0000-0001-8938-6867)
- Tobias B. Huber (ORCID: https://orcid.org/0000-0001-7175-5062)
- Rusan Catar (ORCID: https://orcid.org/0000-0002-7000-7860)
- Ola Al-Diab
- Christin Sünkel
- Angelika Kusch
Institutions
- Universität Hamburg (DE)
- Aarhus University (DK)
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- BioTez (Germany) (DE)
- Helios Hospital Berlin-Buch (DE)
- Xijing Hospital (CN)
- Charité - Universitätsmedizin Berlin (DE)
- Air Force Medical University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s13293-024-00647-7
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Deutscher Akademischer Austauschdienst
- Deutsche Forschungsgemeinschaft
- Aarhus Universitets Forskningsfond
- Charité – Universitätsmedizin Berlin
- Novo Nordisk Fonden