Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention
DPEP1 is expressed in neurons, glia and endothelial cells of DRG. Oxaliplatin caused allodynia in rats and increased TNF-α expression in DRG neurons. The expression of DPEP1 in neurons and other cells of DRG suggest this protein as a novel strategic molecular target in the prevention of oxaliplatin-induced acute neurotoxicity.
Authors
- Rebeca González-Fernández (ORCID: https://orcid.org/0000-0002-2174-6536)
- Rita Martín-Ramírez (ORCID: https://orcid.org/0000-0001-8170-2933)
- Manuel Morales (ORCID: https://orcid.org/0000-0001-7940-8743)
- Ricardo Gutiérrez (ORCID: https://orcid.org/0000-0002-9195-2706)
- Alberto Mariano Lázaro (ORCID: https://orcid.org/0000-0002-1095-679X)
- Pablo Martı́n-Vasallo (ORCID: https://orcid.org/0000-0002-2220-5774)
- Félix Machín (ORCID: https://orcid.org/0000-0003-4559-7798)
- María Ángeles González-Nicolás (ORCID: https://orcid.org/0000-0002-3514-4616)
- Julio Cesar Grijalva Ávila (ORCID: https://orcid.org/0000-0001-5177-1188)
- María Rosa Arnau (ORCID: https://orcid.org/0000-0002-2941-1626)
- Karen Álvarez-Tosco (ORCID: https://orcid.org/0000-0003-2504-554X)
- Lucio Díaz-Flores
Institutions
- Universidad Complutense de Madrid (ES)
- Universidad de La Laguna (ES)
- Hospital Universitario de Canarias (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Universidad Fernando Pessoa Canarias (ES)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s12868-024-00891-y
- Citations
- 3
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Comunidad de Madrid
- Universidad de La Laguna
- European Commission
- Ministerio de Economía y Competitividad
- Fundación Mapfre
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación