Multiomics integrated analysis and experimental validation identify TLR4 and ALOX5 as oxidative stress-related biomarkers in intracranial aneurysms
Bioinformatics analysis indicated that ALOX5 and TLR4 are the most significant ORGs associated with the pathogenesis of IA. Single-cell sequencing and experiments revealed that the high expression of ALOX5 and TLR4 are closely related to IA. These two genes are promising new targets for IA therapy.
Authors
- Maogui Li (ORCID: https://orcid.org/0000-0002-4569-5315)
- Yunyan Wang (ORCID: https://orcid.org/0009-0004-5822-4274)
- Jingzheng Liu
- Xiang Guo (ORCID: https://orcid.org/0009-0005-9940-9037)
- Tao Li (ORCID: https://orcid.org/0000-0002-7988-3090)
- Yu Han (ORCID: https://orcid.org/0000-0003-1462-1118)
- Zhimin Zhao (ORCID: https://orcid.org/0000-0002-3384-2365)
- Weiying Zhong
- Yangyang Xu (ORCID: https://orcid.org/0000-0002-7267-3381)
- Xinlong Ma (ORCID: https://orcid.org/0000-0001-8932-3110)
- Donghai Wang
- Lvyin Luo
- Debin Kong
- Yuxiang Dai (ORCID: https://orcid.org/0000-0003-2479-8996)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-15
- DOI
- https://doi.org/10.1186/s12974-024-03226-0
- Citations
- 17
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- Natural Science Foundation of Shandong Province
- Nature