Early, Robust Mucosal Secretory Immunoglobulin A but not Immunoglobulin G Response to Severe Acute Respiratory Syndrome Coronavirus 2 Spike in Oral Fluid Is Associated With Faster Viral Clearance and Coronavirus Disease 2019 Symptom Resolution
Robust mucosal SIgA early postinfection appears to support faster clearance of SARS-CoV-2 and recovery from COVID-19 symptoms. This research underscores the importance of harmonizing mucosal immune response assays to evaluate new mucosal vaccines.
Authors
- William Clarke
- Zoe O Demko (ORCID: https://orcid.org/0000-0003-2122-820X)
- Fatimah S. Dawood (ORCID: https://orcid.org/0000-0002-6609-376X)
- Barbara Detrick (ORCID: https://orcid.org/0000-0002-3776-4210)
- Maria Deloria Knoll (ORCID: https://orcid.org/0000-0001-9041-2671)
- Christopher D. Heaney (ORCID: https://orcid.org/0000-0003-3211-8495)
- Nora Pisanic (ORCID: https://orcid.org/0000-0002-0042-9232)
- Ruth A. Karron (ORCID: https://orcid.org/0000-0002-4448-4946)
- Yukari Carol Manabe (ORCID: https://orcid.org/0000-0001-8619-5598)
- Vic Veguilla (ORCID: https://orcid.org/0000-0002-0610-4316)
- Kate Kruczynski (ORCID: https://orcid.org/0000-0002-2702-6265)
- Marissa K. Hetrich (ORCID: https://orcid.org/0009-0005-2737-4322)
- Annukka A.R. Antar (ORCID: https://orcid.org/0000-0002-6775-1103)
- Kristoffer Spicer
- David Lee Thomas (ORCID: https://orcid.org/0000-0003-1491-1641)
- Xueyan Zhang (ORCID: https://orcid.org/0000-0001-7854-7266)
Institutions
- Centers for Disease Control and Prevention (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1093/infdis/jiae447
- Citations
- 12
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- Henry M. Jackson Foundation
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases
- National Institute of Environmental Health Sciences