Research Progress on the Involvement of PI3K-AKT Signaling Pathway in the Pathogenesis of Osteoporosis

Osteoporosis is a systemic skeletal disorder characterized by decreased bone mineral density, deterioration of bone microarchitecture, and an elevated susceptibility to fractures. The PI3K-AKT signaling pathway plays a pivotal role in regulating cell survival, proliferation, and differentiation, and is indispensable for normal bone metabolism. Its involvement in the pathogenesis and progression of osteoporosis has not been comprehensively addressed. To elucidate the role of the PI3K-AKT signaling pathway in osteoporosis, particularly its regulation of osteoblast and osteoclast activity and function in autophagy, this review comprehensively summarizes the impact of the PI3K-AKT signaling pathway on bone remodeling processes and recent research advancements, providing valuable references for related disease studies.