MiR-24-3p modulates cardiac function in doxorubicin -induced heart failure via the Sp1/PI3K signaling pathway
Dox induces cardiomyocyte damage, impairs cardiac function, and promotes cardiomyocyte apoptosis and oxidative stress. Silencing miR-24-3p offers a protective effect by activating the Sp1/PI3K signaling pathway in heart failure.
Authors
- Guojian Xiang
- Jun Ke (ORCID: https://orcid.org/0009-0004-6918-2807)
- Linwen Zeng (ORCID: https://orcid.org/0000-0003-2127-7888)
- Yonghong Zheng (ORCID: https://orcid.org/0000-0002-6573-4430)
- Chao Yang (ORCID: https://orcid.org/0000-0002-5328-0355)
- Huizhen Yu (ORCID: https://orcid.org/0000-0002-6845-5197)
- Jiancheng Zhang (ORCID: https://orcid.org/0000-0002-2820-0851)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1016/j.cellsig.2024.111407
- Citations
- 8
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.28
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Technology Project