A description of lineage 1 Mycobacterium tuberculosis from papua, Indonesia
Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region.
Authors
- Hidayat Trimarsanto
- Guy Edward Thwaites (ORCID: https://orcid.org/0000-0002-2858-2087)
- Reinout van Crevel
- Nguyễn Thụy Thương Thương (ORCID: https://orcid.org/0000-0001-8733-692X)
- Philip Ashton (ORCID: https://orcid.org/0000-0002-1545-9661)
- Iqbal Elyazar (ORCID: https://orcid.org/0000-0003-3115-5059)
- Bachti Alisjahbana (ORCID: https://orcid.org/0000-0003-3745-8229)
- Safarina G. Malik (ORCID: https://orcid.org/0000-0002-7258-2586)
- Clarissa A. Febinia (ORCID: https://orcid.org/0000-0002-6918-8529)
- Kevin Baird
- Raph L Hamers (ORCID: https://orcid.org/0000-0002-5007-7896)
- Lidya Chaidir (ORCID: https://orcid.org/0000-0001-5661-4050)
- Hanif Ahmad Kautsar Djunaedy
Institutions
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- Angkor Hospital for Children (KH)
- Eijkman Institute for Molecular Biology (ID)
- Radboud University Medical Center (NL)
- University of Indonesia (ID)
- Menzies School of Health Research (AU)
- Dr. Hasan Sadikin General Hospital (ID)
- Oxford University Clinical Research Unit (VN)
- Oxford University Clinical Research Unit Indonesia
- Padjadjaran University (ID)
Publication Details
- Journal
- Tuberculosis
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1016/j.tube.2024.102568
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Wellcome
- Wellcome Trust