Microbial synthesis of sedoheptulose from glucose by metabolically engineered Corynebacterium glutamicum
We achieved a sedoheptulose concentration of 24 g/L with a yield of 0.4 g/g glucose in a 1 L fermenter, marking the highest value up to date. The produced sedoheptulose could further function as feedstock for synthesising structural seven-carbon sugars through coupling with enzymatic isomerisation, epimerisation and reduction reactions.
Authors
- Yinlu Liu (ORCID: https://orcid.org/0000-0002-4095-5464)
- Jiangang Yang (ORCID: https://orcid.org/0000-0001-9463-8862)
- Min Wang (ORCID: https://orcid.org/0000-0002-4060-1375)
- Yuanxia Sun (ORCID: https://orcid.org/0000-0002-8160-4564)
- Wan Song
- Qianzhen Dong (ORCID: https://orcid.org/0009-0006-4073-5783)
- Wenwen Pei
- Yanhe Ma (ORCID: https://orcid.org/0000-0003-0616-8632)
- Yan Zeng
Institutions
- Tianjin University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s12934-024-02501-2
- Citations
- 8
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China