Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma
In summary, for the first time, we demonstrated the potential of reprogramming macrophages ex-vivo with HDAC6 inhibitors as a viable macrophage cell therapy to treat solid tumors.
Authors
- Karthik Musunuri
- Xintang Li (ORCID: https://orcid.org/0009-0002-4974-4732)
- Maho Shibata (ORCID: https://orcid.org/0000-0002-7056-3939)
- Alejandro Villagra
- Bryan Weselman
- Brett A. Shook (ORCID: https://orcid.org/0000-0001-5740-2244)
- Duncan J. Wardrop (ORCID: https://orcid.org/0000-0002-1234-5626)
- Anélia Horvath (ORCID: https://orcid.org/0000-0003-4117-013X)
- Andrew Pletcher (ORCID: https://orcid.org/0000-0001-8010-6507)
- Katherine B. Chiappinelli (ORCID: https://orcid.org/0000-0001-9241-9105)
- Rohan Fernandes (ORCID: https://orcid.org/0000-0001-9439-4626)
- Satish Noonepalle (ORCID: https://orcid.org/0000-0002-0346-3882)
- Erica Palmer
- Eduardo Sotomayor
- Maria Gracia-Hernandez (ORCID: https://orcid.org/0000-0001-9334-8177)
- Norman Lee (ORCID: https://orcid.org/0000-0001-6198-710X)
- Anatoly Dritschilo (ORCID: https://orcid.org/0000-0002-7120-097X)
- Christian Zevallos‐Delgado (ORCID: https://orcid.org/0000-0001-7078-3782)
- Michael J. Berrigan (ORCID: https://orcid.org/0009-0009-7037-8758)
- Nima Aghdam (ORCID: https://orcid.org/0000-0001-8078-0438)
- Hawa Coulibaly
- Tessa Knox
Institutions
- Georgetown University (US)
- George Washington University (US)
- Georgetown University Medical Center (US)
- Tampa General Hospital (US)
- University of Illinois Chicago (US)
- United Therapeutics (United States) (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s13046-024-03182-w
- Citations
- 18
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Cancer Research Institute
- George Washington University
- National Institutes of Health
- National Cancer Institute