RBM39 Enhances Cholangiocarcinoma Growth Through EZH2-mediated WNT7B/β-catenin Pathway
This study discloses a novel RBM39-EZH2-β-catenin signaling axis that is crucial for CCA growth. Our findings suggest that simultaneous inhibition of RBM39 and EZH2 presents a promising therapeutic strategy for CCA treatment.
Authors
- Nianli Liu (ORCID: https://orcid.org/0000-0002-0602-6709)
- Jinqiang Zhang (ORCID: https://orcid.org/0000-0002-4541-240X)
- Weina Chen (ORCID: https://orcid.org/0000-0002-9474-6262)
- Tong Wu (ORCID: https://orcid.org/0000-0003-3792-0153)
- Wenbo Ma (ORCID: https://orcid.org/0000-0003-3273-5960)
Institutions
- Tulane University (US)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101404
- Citations
- 8
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Institutes of Health