Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8+ T cell exhaustion
Our study manifested the therapeutic potential of targeting sEVs-transmitted circ_0001947 to prohibit CD8<sup>+</sup> T cell exhaustion and immune resistance in GC.
Authors
- Bibo Tan (ORCID: https://orcid.org/0000-0001-6852-6947)
- Hongyue Tang
- Wenbo Liu (ORCID: https://orcid.org/0000-0003-2560-0777)
- Yong Li (ORCID: https://orcid.org/0000-0002-2592-5128)
- Yingying Wang (ORCID: https://orcid.org/0000-0002-3457-5393)
- Mingming Zhang (ORCID: https://orcid.org/0000-0001-8480-0280)
- Bingyu Wang (ORCID: https://orcid.org/0000-0001-5865-4849)
- Buyun Song
- Chao Song (ORCID: https://orcid.org/0000-0003-0611-4298)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s12951-024-02826-5
- Citations
- 16
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Health Commission of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology
- Hebei Medical University