Maternal Cytomegalovirus (CMV) Serology: The Diagnostic Limitations of CMV IgM and IgG Avidity in Detecting Congenital CMV Infection
A negative maternal CMV IgM in the second trimester cannot exclude cCMV infection. While CMV IgG avidity testing and analysis of stored frozen first-trimester maternal blood samples provide valuable insights, they have limitations. CMV PCR performed on amniotic fluid is a useful prenatal diagnostic tool. For cases of unexplained fetal abnormalities or death, autopsy and placental examination are recommended.
Authors
- Weiming Yu (ORCID: https://orcid.org/0000-0002-8408-2888)
- Ian Suchet
- Rati Chadha (ORCID: https://orcid.org/0000-0002-7557-4442)
- Hong Zhou (ORCID: https://orcid.org/0000-0002-5104-3196)
- David Somerset
- Elaine S. Chan (ORCID: https://orcid.org/0000-0001-5260-5798)
- Lawrence de Koning (ORCID: https://orcid.org/0000-0003-2877-4377)
- Verena Kuret (ORCID: https://orcid.org/0000-0002-4947-8326)
- Mary Ann Thomas (ORCID: https://orcid.org/0009-0006-8855-7445)
- Julie Lauzon
- Elaine Poon
- Nancy Soliman (ORCID: https://orcid.org/0000-0001-8057-2903)
Institutions
- University of Calgary (CA)
- Alberta Children's Hospital (CA)
Publication Details
- Journal
- Pediatric and Developmental Pathology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1177/10935266241253477
- Citations
- 7
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 2.71