The Effect of SGLT2 Inhibition on Brain-related Phenotypes and Aging: A Drug Target Mendelian Randomization Study
Our study supported that SGLT2 inhibition increases father's attained age, cognitive function, and intelligence, which was mediated through brain images of different brain regions. Future studies are needed to investigate whether a similar effect could be observed for users of SGLT2 inhibitors.
Authors
- Yufang Bi (ORCID: https://orcid.org/0000-0002-4829-5915)
- Lin Hong (ORCID: https://orcid.org/0000-0002-8117-7427)
- Jieli Lu (ORCID: https://orcid.org/0000-0003-1317-0896)
- Huiling Zhao (ORCID: https://orcid.org/0000-0002-8816-2447)
- Chaoyue Wang (ORCID: https://orcid.org/0000-0001-9402-1563)
- Yu Xu (ORCID: https://orcid.org/0000-0003-1045-8309)
- Shan Luo (ORCID: https://orcid.org/0000-0003-3368-9935)
- Shiu Lun Au Yeung (ORCID: https://orcid.org/0000-0001-6136-1836)
- Zhiyun Zhao (ORCID: https://orcid.org/0000-0001-5950-2732)
- Xueyan Wu (ORCID: https://orcid.org/0000-0001-9127-7854)
- Zhihe Chen (ORCID: https://orcid.org/0000-0001-8294-6729)
- Ruizhi Zheng (ORCID: https://orcid.org/0000-0002-2068-7597)
- Tiange Wang (ORCID: https://orcid.org/0000-0003-0723-489X)
- Guang Ning (ORCID: https://orcid.org/0000-0002-5754-7635)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-6623-6839)
- Weiqing Wang (ORCID: https://orcid.org/0000-0001-6027-3084)
- Haoyu Liu
- Yu‐Hong Chen (ORCID: https://orcid.org/0009-0009-8356-0153)
- Mian Li (ORCID: https://orcid.org/0000-0001-6514-2729)
- Min Xu (ORCID: https://orcid.org/0000-0003-3930-8718)
- Hui Ying
- Qianqian Yang (ORCID: https://orcid.org/0009-0008-0195-833X)
- Shuangyuan Wang (ORCID: https://orcid.org/0000-0002-1060-492X)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- University of Bristol (GB)
- University of Hong Kong (HK)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1210/clinem/dgae635
- Citations
- 9
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- National Key Research and Development Program of China