Pharmacokinetics and safety of daptomycin administered subcutaneously in healthy volunteers: a single-blinded randomized crossover trial
Single-dose SC daptomycin infusion proved to be safe, exhibiting a bioequivalent AUC0-24 compared with the IV route. The SC route emerges as a potential and effective alternative when IV administration is not possible.
Authors
- Sylvie Brucato
- Jean‐Jacques Parienti (ORCID: https://orcid.org/0000-0002-4774-5590)
- Marie‐Clémence Verdier (ORCID: https://orcid.org/0000-0001-6595-8154)
- Aurélie Baldolli
- Emmanuelle Comets (ORCID: https://orcid.org/0000-0002-9150-9886)
- Laure Peyro‐Saint‐Paul (ORCID: https://orcid.org/0000-0003-0301-1058)
- Charles Maurille (ORCID: https://orcid.org/0000-0001-5772-5377)
- Christian Créveuil (ORCID: https://orcid.org/0000-0002-5506-5296)
- Jocelyn Michon
- S. Dargère
- Renaud Verdon
Institutions
- Inserm (FR)
- École des Hautes Études en Santé Publique (FR)
- Normandie Université (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- CIC Rennes (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Dynamique Microbienne associée aux Infections Urinaires et Respiratoires
- Université de Rennes (FR)
- Université de Rouen Normandie (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1093/jac/dkae324
- Citations
- 4
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Région Normandie