A - 15 Convergent Validity between Standard Neuropsychological Assessment and Web-Based Voice-Recognition Neuropsychological Assessment (Intraneuron)

Abstract Objective The prevalence of mild cognitive impairment (MCI) remains high, and often cases may go undetected. The gold standard for detection of cognitive decline is neuropsychological assessment. However, access to neuropsychological assessment can be impacted by geographic and financial limitations. Prior research has determined that electronic-based testing is effective in detecting cognitive change. This study aimed to investigate a convergent validity between standard neuropsychological assessment (SNA) and a web-based, voice-recognition neuropsychological assessment tool (Intraneuron). Method 75 participants from a community-based neurology practice completed SNA and Intraneuron. Intraneuron is comprised of an auditory list learning/recall test and verbal fluency tests (F/A/S, animals). Pearson correlations were conducted to examine the convergent validity between SNA and Intraneuron. A McNemar cross tabulation analysis was utilized to compare the proportions of detected “normal” and “abnormal” screening for SNA (based on clinical diagnosis) and Intraneuron (utilizing 1SD and 1.5SD below the mean as cutoffs). Results There were moderate, positive correlations between the SNA and Intraneuron: animals (r = 0.43, p < 0.001), F/A/S (r = 0.67, p < 0.001), delayed word list recall (r = 0.49, p < 0.001). The McNemar test showed that the classification between SNA and Intraneuron were similar at 1SD and 1.5SD. Conclusions The study demonstrated convergent validity SNA and Intraneuron. Results suggest that the Intraneuron is equivalent in the detection of early cognitive decline compared to SNA. This data provides support for the value of a web-based screening tool and the potential to maximize utilization across multiple settings and improve early detection of cognitive decline.