B - 14 NEO Personality Inventory-Revised (NEO-PI-R) Domains Compared across BSNIP-2 Biotypes for Psychosis Spectrum Disorders

Abstract Objective The NEO Personality Inventory-Revised (NEO-PI-R) is commonly used to assess the Big Five personality traits: Neuroticism (N), Extroversion (E), Openness (O), Conscientiousness (C), and Agreeableness (A). This study compared NEO-PI-R personality factor composite scores across novel biological and neuropsychological characterizations of psychotic spectrum disorders (“biotypes”) derived by the Bipolar Schizophrenia Network for Intermediate Phenotypes (B-SNIP) consortium. Understanding personality patterns in more specific characterizations of psychotic spectrum disorders may shed light on behavioral patterns, including help-seeking in psychosis spectrum disorders. Methods Participants were 1086 individuals with a psychosis spectrum disorder grouped by biotype rather than DSM diagnosis who completed the NEO-PI-R. Results One-way ANOVAs were used to assess potential biotype group differences regarding NEO-PI-R traits. Post-hoc comparisons revealed that healthy controls endorsed more extroverted, agreeable, conscientious and less neurotic personality traits compared to the biotypes collectively. Traits of openness differentiated biotypes such that Biotype 3 endorsed more openness than Biotypes 1, 2 and Healthy Controls. Conclusions In addition to normal range cognitive abilities, less symptomatology, and fewer electrophysiological/imaging abnormalities, the present findings indicate that the Biotype 3 group endorsed more openness than the other patient groups. Like the Biotype 1 and 2 groups, internalizing symptomatology was present in the Biotype 3 group (less agreeableness, more neuroticism, less conscientiousness). Increased executive functioning, flexibility, problem-solving, and/or self-monitoring could be important factors contributing to the greater openness of the Biotype 3 group.