Single-cell RNA sequencing analysis of peripheral blood mononuclear cells in PD-1-induced renal toxicity in patients with lung cancer
In conclusion, R-irAEs are associated with immune cell dysfunction. DEGs and their enriched pathways identified in CD4<sup>+</sup> T cells and CD8<sup>+</sup> T cells play important roles in the development of renal irAEs related to anti-PD-1 therapy. These findings offer fresh perspectives on the pathogenesis of renal damage caused by anti-PD-1 therapy.
Authors
- Shusu Liu
- Peiyu Lu
- Yuan‐Han Yang (ORCID: https://orcid.org/0000-0002-1918-9021)
- Bixia Yang (ORCID: https://orcid.org/0000-0002-4997-2834)
- Min Yang (ORCID: https://orcid.org/0000-0002-3846-261X)
- Hua Zhou
Institutions
- Soochow University (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s12882-024-03754-0
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57