Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Eleven novel clerodane-type diterpenoids, grewiifopenes A-K (1-4 and 12-18), along with nine known compounds (5-11, 19, and 20) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations. The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC<sub>50</sub> values ranging from 0.3 to 2.9 μM. Isocaseamembrin E (7) exhibited antibacterial activity against Staphylococcus aureus, while isocaseamembrin E (7), corymbulosin X (8), caseargrewiin A (9), kurzipene A (10), and balanspene F (11) exhibited antibacterial activity against Bacillus cereus.
Authors
- Panita Khlaychan (ORCID: https://orcid.org/0009-0003-2074-9270)
- Chulabhorn Mahidol
- Supanna Techasakul (ORCID: https://orcid.org/0000-0002-6540-5362)
- Nanthawan Reuk-Ngam (ORCID: https://orcid.org/0000-0003-1672-1569)
- Somsak Ruchirawat
- Vilailak Prachyawarakorn
- Phanruethai Pailee
- Paratchata Batsomboon (ORCID: https://orcid.org/0000-0001-6470-9084)
- Poonsakdi Ploypradith (ORCID: https://orcid.org/0000-0003-2893-1598)
- Wiriya Yaosanit
- Theerawat Thananthaisong
Institutions
- Chulabhorn Graduate Institute (TH)
- Department of National Parks Wildlife and Plant Conservation (TH)
- Chulabhorn Research Institute (TH)
- Office of the Higher Education Commission (TH)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1007/s13659-024-00475-7
- Primary Topic
- Plant-Derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Thailand Science Research and Innovation